Resurfacing work on Cross Road, Langtoft, will see it closed to traffic from Thursday for about three weeks.
Diversions will be along Baston Outgang Road and Main Street to Deeping Road, the A15 and A1175 Littleworth Drove.
Working hours on the road over the next three weeks will be from 7.30am to 5pm, but people living and working in Cross Road will be given access.
A Lincolnshire County Council spokesman said: “We apologise for any inconvenience caused by this essential maintenance.”